The concept of human gene therapy came on the heels of fundamental discoveries on the nature and working of the gene. However, realistic prospects to correct the underlying cause of recessive genetic disorders through the transfer of wild‐type alleles of defective genes had to wait for the arrival of recombinant DNA technology. These techniques permitted the isolation and insertion of genes into the first recombinant delivery systems. The realization that viruses are natural gene carriers provided inspiration for gene therapy and, (...) as engineered vectors, viruses became prominent gene delivery vehicles. Nonetheless, when put in the context of human and non‐human primate studies, all vectors fell short of success regardless of their viral or non‐viral origin. Recognition of issues such as inefficient gene transfer and short‐lived or scant expression in the relevant cell type(s) prompted researchers to refine and develop several gene delivery systems, in particular those based on retroviruses, adeno‐associated viruses and adenoviruses. Concomitantly, available technology was deployed to tackle disorders that require few genetically corrected cells to attain therapy. BioEssays 27: 506–517, 2005. © 2005 Wiley periodicals, Inc. (shrink)

A través de una reconstrucción de la evolución de su pensamiento, en este artículo se estudia la utilización de infinitesimales por parte de Newton. Se distingue entre dos concepciones sucesivas de lo que denominó momento. A la primera de estas entidades la caracterizó como un infinitesimal, pero a la segunda (un indivisible generador de magnitudes finitas, que interviene en su método de las primeras y últimas razones) no la consideró como tal. Se entiende así su manifestación de rechazo a los (...) infinitesimales, formulada en una segunda etapa, y se ve que las dudas arrojadas por algunos investigadores sobre la veracidad de tal manifestación se deben a una determinada interpretación de esta última concepción de momento.This paper discusses Newton’s recourse to infinitesimals through the reconstruction of the evolution of his thought. Two successive concepts of what he termed “moment” are told apart. The first of those entities was characterized by him as an infinitesimal, while the second -an indivisible generating finite magnitudes, present in his method of first and last reasons- was not considered such an entity. This move makes understandable his express rejection of infinitesimals in the second stage, and exposes the doubts of some scholars about the sincerity of Newton’s rejection as due to a peculiar interpretation of his last concept of “moment”. (shrink)

Jean Buridan developed his theory of consequence within a semantical framework compatible with what we now call token-based semantics. In his Treatise on Consequences and Sophismata, Buridan showed...

-- t. 2. Trayectoria de su pensamiento filosófico.

Diez, M.A. Discurso ... -- Urdaneta, A. Contestación ...

The rise of foundational dualism and the eclipse of the body -- "Body am I entirely, and nothing else": non-reductive materialism and the struggle against dualism -- Toward a materialist phenomenology of religion -- The phenomenology of embodiment and the study of religion -- Religious bodies as social artifacts -- Holding social constructionism in check: the recovery of the active, lived body -- A cultural neurophenomenology of religion: enter the embodied mind -- The eclipse of practice: textualism at large -- (...) "Ceci n'est pas un texte": from textualism to practice -- Expanding the conversation on emplaced religion -- Mobility, networks, and ecology. (shrink)

This article examines the dynamics that have turned a recent Marian apparition on the window of a bank in Clearwater, Florida, from a local into a global phenomenon. Drawing from theories of globalization, we show how the apparition exemplifies what sociologist Roland Robertson refers to as the mutually implicative `universalization of particularism and the particularization of universalism'. Among the factors analyzed are global pilgrimage, transnational migration, mediascapes and the Vatican's New Evangelization initiative. On the basis of this case study, the (...) article argues for the need to go beyond secularization theory - the dominant modernist approach to religion and social change - and to adopt a flexible, polymethodological framework that takes into account the complex, and often contradictory, relations between the local and the global and the mediating roles religion plays. (shrink)

The ancient commentaries on Aristotle's Peri Hermeneias give us important elements to understand more clearly some difficult passages of this treatise. In the case of the indefinite names and verbs, these commentaries reveal a doctrine which explains not only the nature of the indefinites, but also why Aristotle introduces these kinds of term in Peri Hermeneias. The coherence and explanatory capacity of this doctrine is entirely absent in modern exegesis of Peri Hermeneias. This fact has important implications: it can make (...) us to think whether there will be another topics in which the ancient commentators are still indispensable to understand Aristotle. It can also make us to think to what extent a profounder reflection of the ancient commentators can modify our idea of Aristotle and the ancient world. (shrink)

This paper introduces an axiomatisation for equational hybrid logic based on previous axiomatizations and natural deduction systems for propositional and first-order hybrid logic. Its soundness and completeness is discussed. This work is part of a broader research project on the development a general proof calculus for hybrid logics.

Vítima, quer do contexto, quer da sua recepção, a obra de Eric Weil (1904-1977), editada entre os anos 50 e 70 do século passado, não tem obtido o devido acolhimento pela comunidade filosófica. Se as interpretações magistrais de Kant (Problèmes kantiens. Paris: Vrin, 1970) e de Hegel (Hegel et l’état. Paris; Vrin, 1950) constituem referências cada vez mais frequentes nos trabalhos da especialidade (os quais persistem, contudo, em ignorar os importantes artigos sobre a filosofia dos dois autor...

Com este artigo, procurámos expor a dinâmica que assiste à Filosofia do Conhecimento de Francisco Vieira de Almeida (1888-1962), Professor da Faculdade de Letras da Universidade de Lisboa de 1915 a 1958, por um lado, apresentada como acesso privilegiado à prática filosófica, por outro, entendida como exercício de sistematização que recusa a fixação num sistema, por fim, atravessada pela intenção de promover a osmose entre o conhecimento de «tipo-filosofia» e o de «tipo-ciência», surpreendendo a gestualidade dessa ética do filosofar naquela (...) que é tida, consensualmente, como sua obra-prima, Pontos de Referência, publicada em 1961. As sinuosidades particulares de uma tal pragmática, resistindo deliberadamente a todo o esforço de circunscrição, levaram-nos a cruzar um primeiro nível de leitura, orientado para evidenciar os traços gerais, e um segundo, ocupado com problemas de teor mais específico. (shrink)

O que é posto em comum depende, em grande parte, de processos textuais específi cos que funcionam como condições de possibilidade pragmático-narratológicas da partilha dos sentidos que circulam pelo meio da linguagem. Tal implica que o simples uso corrente da linguagem, ao contrário do que é usual supor, ainda que indispensável, não seja sufi ciente para gerar essa comunidade, pois que nem todos os dispositivos linguísticos estão vocacionados para favorecer a convergência. Neste artigo, pretendemos, por conseguinte, reflectir sobre uma dessas (...) condições, a de que uma nova enunciação, para se tornar comum, tenha sempre de retomar uma versão enunciativa, já consolidada, não apenas formalmente, mas, também, no que respeita a sequências textuais específicas. Para o efeito, estendemos o conceito de retomada que, na filosofia de Eric Weil, surge no âmbito da Lógica da Filosofia, à totalidade da comunicação com pretensão a fazer sentido. Trata-se, portanto, de pensar com Weil, para lá de Weil, num exercício de (in)fidelidade e distanciação que constitui, em si mesmo, uma forma de o retomar. (shrink)

Apresenta-se, traduz-se e anota-se a Carta a Paul Landois, datada de 1756, que contém uma síntese das principais teses da filosofia moral de Diderot.

Cet article reprend les textes de Kant sur le tremblement de terre de Lisbonne pour mettre en évidence l’intention philosophique générale qui les soutient, à la fois gnoséologique, épistémologique et métaphysique. Compris comme essais d’application de sa théorie des premiers principes de la connaissance, ils peuvent alors retrouver leur place dans l’ensemble de la production du philosophe dans cette année de 1755 et s’inscrire aisément dans sa recherche des fondements d’une science sensée de la nature.

Addressing the study of human action from Mises’s perspective of the praxeological method is in itself highly controversial. Particularly, if it attempts to identify the ultimate basis of human development, it will face unmanageable problems in analytical and normative terms. The incapability to withdraw from the socalled self-evident judgments comes together with the refusal of the elements that address its operability. Dependent of a soft well-being concept, it is unable to establish interpersonal comparisons, and this in turn frustrates any kind (...) of attempt to design a convincing social justice theory. A Hegelian perspective brings order to and improves both the moral and the operability dimension of the praxeological interpretation of economics. (shrink)

El propósito de este trabajo se enmarca en la necesidad de esclarecer la naturaleza última del capitalismo que cristaliza ideológicamente desde las bases fecundas de la modernidad. Desde el examen crítico de los trabajos de S. Žižek realizaremos una introspección analítica que nos permita arrojar luz no solo a cómo el capitalismo configura la realidad de esta época sino al modo en que gestiona sus límites y fija su devenir. Se concluirá que el capitalismo lejos de ser el resultado político (...) de un proceso socio-económico caprichoso resulta ser la materialización de un instante de la conciencia moral que destinada a emanciparse se encuentra todavía en su comienzo. (shrink)

Este volume oferece o primeiro conjunto de artigos exclusivamente dedicados à noção de «retomada», tal como a entendeu Eric Weil (1904-1977), escritos por investigadores oriundos de Portugal, França, Brasil, Itália, Roménia, Burkina Faso e Chile. Nascido na Alemanha, Eric Weil foi discípulo de Ernst Cassirer que o orien­tou no estudo dos filósofos do Renascimento, como Pietro Pomponazzi e Marsílio Ficino. Naturalizado francês, após ter sido obrigado a abandonar o país de origem, contra o qual...

Com este conjunto de treze artigos introdutórios, pretende-se apontar e, parcialmente, preencher uma lacuna significativa nos estudos sobre a Filosofia em Portugal e no Brasil. Com efeito, uma investigação bibliográfica tornará facilmente manifesto que a Filosofia do Conhecimento, enquanto tal, com os seus problemas específicos e as suas categorias próprias, não tem figurado, com uma assiduidade à medida da sua representatividade, na agenda daqueles que se dedicam à interpretação das proposta...

Le volume que nous présentons ici est le résultat d’un travail collectif entrepris pour la première fois exclusivement sur la notion de reprise, telle que l’a proposée Eric Weil (1904-1977), par des chercheurs venus du Portugal, de France, du Brésil, d’Italie, de Roumanie, du Burkina Faso et du Chili. Né en Allemagne, Eric Weil a étu­dié avec Ernst Cassirer qui l’a dirigé sur des recherches concernant les philosophes de la Renaissance, comme Pietro Pomponazzi et Marsile Ficin. Naturalisé fran...

Los modelos de escritura están experimentando grandes transformaciones como consecuencia de la revolución tecnológica contemporánea. Aunque los cibertextos y los hipertextos no son realidades exclusivas de la cultura digital, pues se dan en contextos culturales precedentes, aportan formas de pensamiento alternativas, que pasan por implicaciones epistemológicas –el pensamiento en red–, estéticas –reformulación de la autoría– y éticas –exigen un compromiso por parte del receptor. En este trabajo se abordará dicha coyuntura comparando las escrituras literarias Hypertext Hotel (1992) y Leyenda mayor (...) de Ian Curtis (2017) con las escrituras audiovisuales +101 (2012) y Quién lo impide (2018) con el objetivo de comprender las transformaciones que suponen tanto en la experiencia estética como en el campo cultural digital. Para ello, se empleará una metodología comparatista que tenga en cuenta las concomitancias entre las dos series de escrituras. (shrink)

El desarrollo de la neurociencia ha permitido, en las últimas décadas, espectaculares avances en torno al mejor conocimiento de diferentes prácticas humanas desde las bases neurofisiológicas del funcionamiento cerebral. A pesar de que aún nos encontramos en la «prehistoria» del descifrado funcional del más complejo órgano que conocemos en el universo, es un momento adecuado para hacer un balance operativo, desterrando algunas falsedades y aprovechando algunos datos consolidados para su aplicación a la enseñanza y a la praxis de la escritura (...) creativa. De manera sintética, abordaremos algunas claves sobre la creatividad en general, para centrarnos en la creatividad verbal estética, tanto en su expresión oral como a través de los cambios cerebrales que se operan en el proceso de aprendizaje de la lectura. Reflexionaremos acerca de la complejidad de nuestras representaciones mentales vinculadas, por ejemplo, con el discurso poético verbal, ofreceremos algunas indicaciones sobre la importancia de la escritura como potenciador de nuestra reserva cognitiva, destacando algunas orientaciones prácticas para potenciar la creatividad en la experiencia de esa misma escritura. Insistiremos en la importancia de la emoción y la atención, así como en la interconexión entre inteligencia racional e inteligencia emocional en los ámbitos de la escritura y la lectura. Finalizaremos con un análisis de las nuevas prácticas de lectura y escritura desarrolladas en el tercer entorno, nuevas narrativas construidas en el nuevo paradigma tecnológico que han posibilitado nuevos ámbitos creativos para la escritura, insistiendo en los conceptos de ‘transmedialidad’, ‘literacidad digital’, ‘hipertextualidad’, ‘multimodalidad’ y su incidencia en nuestra actividad cerebral. (shrink)

In this paper I argue for a novel interpretation of Shepherd’s notion of selfhood. In distinction to Deborah Boyle’s interpretation, I contend that Shepherd differentiates between the mind and the self. The latter, for Shepherd, is an effect arising from causal interactions between mind and body – specifically those interactions that give rise to our present stream of consciousness, our memories, and that can unite these two. Thus, the body plays a constitutive role in the formation of the self. The (...) upshot of this interpretation is that it can dissolve the problem of individuating mind that Boyle identifies. Briefly, the problem consists in Shepherd seemingly individuating minds in terms of their associated bodies and bodies in terms of the minds they are united with. My interpretation, however, allows to see that Shepherd neither wants nor needs to individuate the mind in isolation of the body and to read the passages, in which the problem seems to arise, as being about what makes living beings individual – with mind and body both playing a crucial role in this context. (shrink)

This bibliographical study involved first the exploitation of four data-banks: Medline, CNRS, Bioethics and AIDS, with the following key words (in conjunction with AIDS): ethics, human rights, confidentiality, legislation, jurisprudence. A total of 412 references were listed between 1983 and the end of 1987. Examination of the quantitative increase of articles over these years shows that, while references to AIDS and/or HIV infection--referred to as 'AIDS' for brevity--increased by about one third per year, the number of papers treating ethical problems (...) linked to AIDS doubled each year. This increase makes it clear that these problems are important and pressing, that they are evolving rapidly and can be given no easy solution. After reading and analysis of accessible articles in readily comprehensible languages, the different themes can be classified in two categories: 1: Measures intended to protect society (starting with the most coercive); quarantine and isolation; discriminatory measures concerning specific groups; non-respect of the confidential nature of medical information; application of the penal code; screening; obligatory declaration and registration; testing of blood given by donors; vaccination and medical innovations, therapeutic assays; information, education. 2. Measures intended to protect the individual: fundamental rights of the patient: his/her right to confidentiality, to information and to treatment; civil rights: civil liberty, right to education, right to work, etc...; rights of the healthy individual: right of those in contact with the patients, safety of hospital staff, of those receiving blood-transfusions, etc... The legislation adopted in the various countries and the main opinions to be found in these articles are listed and analysed, and for each particular theme it is possible to refer to a list of the 232 most important articles. While the debate seems to concentrate on the conflict between the right of society to protect itself against the spread of infection and the 'civil' rights of the infected minorities, our conclusion tends to reduce this antagonism, showing that, particularly as far as the confidential nature of medical information is concerned, measures intended to protect the individual also protect society. (shrink)

Until quite recently, almost no philosophers trained in the continental tradition saw anything of value in realism. The situation in analytic philosophy was always different, but in continental philosophy realism was usually treated as a pseudo-problem. That is no longer the case. In this provocative new book, two leading philosophers examine the remarkable rise of realism in the continental tradition. While exploring the similarities and differences in their own positions, they also consider the work of others and assess rival trends (...) in contemporary philosophy. They begin by discussing the relation between realism and materialism, which DeLanda links closely but which Harman tries to separate. Part Two covers the many different meanings of realism, with the two authors working together to develop an expanded definition of the term. Part Three features a spirited exchange on the respective virtues and drawbacks of DeLanda's realism of attractors and singularities and Harman's object-oriented theory. Part Four shifts to the question of the knowability of the real, as the authors discuss whether scientific knowledge does full justice to reality. In Part Five, they shift the focus to space, time, and science more generally, and here Harman offers a defence of actor-network theory despite its obvious anti-realist elements. Lively, accessible and engaging, this book is the best attempt so far to clarify the different paths for realism in continental philosophy. It will be of great value to students and scholars of continental philosophy and to anyone interested in the cutting-edge debates in philosophy and critical theory today. (shrink)

info:eu-repo/semantics/publishedVersion.

The COVID-19 global health emergency has greatly impacted the educational field. Faced with unprecedented stress situations, professors, students, and families have employed various coping and resilience strategies throughout the confinement period. High and persistent stress levels are associated with other pathologies; hence, their detection and prevention are needed. Consequently, this study aimed to design a predictive model of stress in the educational field based on artificial intelligence that included certain sociodemographic variables, coping strategies, and resilience capacity, and to study the (...) relationship between them. The non-probabilistic snowball sampling method was used, involving 337 people from the university education community in south-eastern Spain. The Perceived Stress Scale, Stress Management Questionnaire, and Brief Resilience Scale were administered. The Statistical Package for the Social Sciences was used to design the architecture of artificial neural networks. The results found that stress levels could be predicted by the synaptic weights of coping strategies and timing of the epidemic, with a predictive capacity of over 80% found in the neural network model. Additionally, direct and significant associations were identified between the use of certain coping strategies, stress levels, and resilience. The conclusions of this research are essential for effective stress detection, and therefore, early intervention in the field of educational psychology, by discussing the influence of resilience or lack thereof on the prediction of stress levels. Identifying the variables that maintain a greater predictive power in stress levels is an effective strategy to design more adjusted prevention programs and to anticipate the needs of the community. (shrink)

Defends a version of the Davidsonian Demonstrative Theory of quotation against proponents of the Fregean Identity Theory.

In this paper we explore in what sense we can claim that affordances, the objects of perception for ecological psychology, are related to normativity. First, we offer an account of normativity and provide some examples of how it is understood in the specialized literature. Affordances, we claim, lack correctness criteria and, hence, the possibility of error is not among their necessary conditions. For this reason we will oppose Chemero’s normative theory of affordances. Finally, we will show that there is a (...) way in which taking advantage of affordances could be considered as possessing a normative character, but only when they are evaluated within the framework of social normative standards in particular situations. This reinforces our claim that affordances, per se, lack normativity and can only be taken to be rule-governed in relation to established normative practices. (shrink)